RNAi SERVICES

At Mirimus, we leverage the powerful mechanism of RNA interference (RNAi) to provide sophisticated gene silencing solutions tailored to your research and therapeutic needs. RNAi offers a precise method to regulate gene expression, silencing specific genes with high accuracy. Our state-of-the-art platform enables the development of a wide array of RNAi triggers, including small interfering RNAs (siRNAs), short hairpin RNAs (shRNAs), and artificial microRNAs (miRNAs). These advanced tools can silence disease-causing genes, validate therapeutic targets, and advance preclinical studies for a range of applications in oncology, neurology, and genetic disorders.

Custom siRNA and shRNA Design

Our team specializes in designing siRNAs and shRNAs that specifically target your gene of interest, providing robust gene knockdown with minimal off-target effects. Using sophisticated bioinformatics tools and extensive knowledge of RNA structure, we optimize these RNA molecules to ensure maximum silencing efficiency while maintaining high levels of specificity.

  • In silico design to identify optimal siRNA and shRNA sequences
  • Validation and testing for gene knockdown efficiency in vitro
  • Custom synthesis and purification of siRNAs and shRNAs to your specifications

Artificial miRNA Development

Mirimus offers advanced artificial miRNA design services, allowing you to tap into natural miRNA pathways to modulate gene expression. Artificial miRNAs can be used to target multiple genes simultaneously, offering a more refined approach to gene regulation. Our artificial miRNAs are engineered to function similarly to endogenous miRNAs, making them ideal tools for exploring complex gene networks, conducting high-throughput studies, or developing therapeutic candidates.

  • Custom miRNA sequences for specific gene targets
  • Dual targeting capabilities for enhanced gene silencing
  • miRNA-mimic constructs for therapeutic and research applications

Comprehensive RNAi Delivery Systems

Effective RNAi therapy relies not only on the design of RNAi molecules but also on efficient delivery systems. At Mirimus, we provide cutting-edge solutions to ensure the reliable transfer of RNAi therapeutics into target cells.

  • Lipid Nanoparticle (LNP) Formulations: Our custom LNP formulations encapsulate RNAi molecules, protecting them from degradation and enabling safe and effective delivery into cells. LNPs have proven to be a key vehicle for delivering siRNAs in vivo, with optimal biodistribution and minimal toxicity.
  • Viral Vector-Based Delivery Systems: For stable, long-term gene silencing, we offer viral vector systems (such as lentiviral or adenoviral vectors) to deliver RNAi sequences into cells. This approach is ideal for sustained RNAi expression and can be used for both in vitro studies and in vivo models.

Target Validation and Therapeutic Development

RNAi is a powerful tool for validating gene targets and exploring their role in disease pathways. Our RNAi therapeutics platform can be used to investigate gene function in preclinical models, providing valuable insights into gene-disease relationships and advancing the development of novel therapies. We work closely with you to design experiments that validate key targets and accelerate the discovery of RNAi-based therapeutics.

  • High-throughput screening for gene function analysis
  • Preclinical validation of RNAi therapeutics in relevant disease models
  • Assistance in transitioning RNAi candidates into clinical development

Our Technology

Why Choose Mirimus for RNAi Services?

With years of experience in RNAi research and drug development, Mirimus is your trusted partner for all your gene silencing needs. Our expert team is dedicated to providing personalized, high-quality services that empower your research and therapeutic development. We prioritize:

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Precision

We use cutting-edge tools and methodologies to design RNAi molecules that achieve precise gene knockdown with high specificity.

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Efficiency

Our custom delivery systems ensure that RNAi molecules are efficiently transferred into target cells, maximizing therapeutic outcomes.

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Innovation

We stay at the forefront of RNAi technologies, constantly advancing our methods to offer the most innovative and effective solutions.

Whether you’re conducting basic research, validating therapeutic targets, or developing RNAi-based therapies, our team is committed to supporting your project at every stage. Discover the potential of RNAi therapeutics with Mirimus and drive your research forward with confidence.

CONTACT US

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760 Parkside Avenue, Suite 206
Brooklyn, NY 11226
info@mirimus.com
+1 (917) 830-6123