Custom Models

Custom models are designed to meet your specific research requirements, incorporating tailored genetic modifications in mice or rats. We collaborate closely with researchers to engineer models with precise mutations, ensuring translatable results for disease studies or therapeutic development.

Inducible RNAi Models

Inducible RNAi models enable reversible gene silencing using RNA interference, controlled by inducible promoters. These models allow researchers to toggle gene expression on or off, facilitating studies of gene function and therapeutic target validation with high precision.

Rare Disease Models

Our rare disease models replicate genetic mutations associated with rare disorders in mice or rats. These models support the development of therapies for underserved conditions, enabling researchers to study disease mechanisms and test potential treatments.

Cancer Models

Cancer models are engineered to recapitulate tumor development and progression, including specific oncogene activations or tumor suppressor knockouts. These models are critical for studying cancer biology, tumor microenvironments, and evaluating novel oncology therapeutics.

Humanized Models

Humanized models incorporate human genes, cells, or tissues into mice or rats to better mimic human physiology and disease. These models enhance translational relevance, particularly for studying human-specific responses to therapies or disease mechanisms.

Reporter Models

Reporter models incorporate fluorescent or luminescent markers to track gene expression or cellular processes in real-time. These models enable non-invasive monitoring of molecular events, ideal for studying gene regulation, cell signaling, or therapeutic responses in vivo.

Cre Models

Cre recombinase models allow for tissue-specific or inducible gene modifications using the Cre-loxP system. These models provide precise control over gene activation or deletion, enabling targeted studies of gene function in specific cell types or developmental stages.

Tet-Transactivator Models

Tet-transactivator models utilize the tetracycline-controlled transcriptional activation system (Tet-On/Tet-Off) to regulate gene expression temporally. These models are perfect for studying dynamic gene regulation, allowing reversible control over gene activity in response to external stimuli.

Syngeneic Models

Syngeneic models involve transplanting mouse-derived tumors into immunocompetent mice of the same genetic background. These models preserve an intact immune system, making them ideal for studying immunotherapy responses and tumor-immune interactions.

Orthotopic Models

Orthotopic models implant tumors or cells into their tissue of origin (e.g., breast cancer cells in mammary tissue), mimicking natural disease environments. These models provide realistic platforms for studying tumor growth, metastasis, and therapeutic efficacy.

PDX Models

Patient-Derived Xenograft (PDX) models implant human tumor tissues directly into immunocompromised mice, preserving the tumor’s genetic and histological features. These models are highly translational, supporting personalized medicine and drug efficacy studies.

Degron Technologies

Degron technology enables the rapid, reversible, and specific removal of a target protein in vivo. It involves tagging the protein with a "degron" sequence and using a small molecule to induce the degradation. This technology offers precise and conditional control over protein levels to study its function.