At Mirimus, we create advanced 2D and 3D cell models that bring biology to life — helping researchers uncover gene function, decode disease mechanisms, and accelerate therapeutic breakthroughs. Our engineered systems closely mimic living tissues, delivering data that translates to real-world outcomes.
From compound screening to mechanistic studies, Mirimus provides reliable, customizable models that turn cellular insights into discovery.
At Mirimus, we recognize the power of advanced in vitro services to drive both discovery research and therapeutic development. Leveraging our expertise in RNAi and CRISPR technologies, we generate custom 2D and 3D cell models that allow researchers to study gene function, disease mechanisms, and therapeutic targets with precision. In addition to creating these models, we design and optimize assays tailored to your research goals and perform drug screening studies that provide clear, actionable insights. Together, these platforms accelerate progress across the research and development pipeline. We prioritize:
Our scientists employ the latest technologies to ensure that every assay is of the highest quality and relevance.
We tailor our services to meet the unique needs of your project, offering flexibility in both assay design and implementation.
With years of experience in cell-based assays and drug development, our team is equipped to tackle even the most complex challenges in drug discovery.
Our 2D cell models, provide an efficient and cost-effective way to screen large numbers of compounds for drug efficacy, toxicity, and mechanism of action. These models are ideal for both low- and high-throughput screening applications, allowing for rapid evaluation of therapeutic candidates with precision and reproducibility.
Low- and High-Throughput Screening: Our streamline large-scale screening campaigns, enhancing throughput and data accuracy while minimizing hands-on time.
Diverse Cell Line Selection: We work with a wide range of cell lines, including primary human cells and immortalized cell lines, to ensure the most relevant model for your specific application.
Quantitative Readouts: With the Incucyte live-cell imaging system, we continuously monitor cell proliferation, morphology, and viability in real time, providing dynamic, quantitative insights into drug activity over time.
Recognizing the limitations of traditional 2D cell models, we offer advanced 3D cell models that more closely replicate the structural and functional complexity of in vivo tissues. These models are particularly valuable for studying more complex biological processes, such as tissue regeneration, cancer growth, and drug resistance.
Organoids: We develop organoid models that mimic the three-dimensional architecture of tissues, providing a more physiologically relevant environment for testing drug candidates.
Improved Predictability: By closely mimicking in vivo conditions, our 3D models offer better predictive power for how a drug will behave in the body.
Enhanced Mechanistic Insights: Our flow cytometers and cell sorters enable us to dissect complex cellular responses in 3D models, allowing for detailed exploration of drug effects on specific cell populations.
Our team is highly skilled at developing and optimizing functional assays that are tailored to your specific research needs. We work closely with you to design assays that assess the biological function of your therapeutic candidates, from cell viability and proliferation to more specialized functions like receptor activation or metabolic activity.
Tailored Solutions: We design assays based on your unique requirements, ensuring that the data you receive is highly relevant to your research goals.
Diverse Assay Types: Using our flow cytometers and fluorescent microscopes, we offer a wide range of readouts, from cellular metabolic activity to complex signal transduction pathways.
Optimization and Scalability: Our assays are optimized for high sensitivity and reproducibility, and can be seamlessly integrated into high-throughput workflows using our advanced systems for larger-scale projects.
Our expertise extends beyond assay development to assay validation, where we rigorously test and validate assays to ensure reliability and accuracy. For mechanistic studies, we help you explore the underlying mechanisms of action of your drug candidates, such as target engagement, signal transduction pathways, and cellular responses.
Mechanistic Pathway Analysis: With tools such as flow cytometry and live-cell analysis using Incucyte, we can design and validate assays that probe specific pathways and molecular targets of your therapeutic candidates, providing deep insights into their function at the cellular level.
Biomarker Identification: Our fluorescent microscopes and flow cytometers are instrumental in identifying and tracking key biomarkers that can be used to measure therapeutic efficacy, toxicity, and mechanisms of action throughout the development process.
High Sensitivity and Specificity: Our validation processes ensure that all assays are rigorously tested for sensitivity, specificity, and reproducibility, providing you with reliable data to support your therapeutic development decisions.
Production of viral vectors for RNAi, Overexpression, and Gene Editing
Engineered microRNA scaffolds for potent gene silencing in vivo (Militello et al, 2025, Scientific Reports)
Engineered microRNA scaffolds for potent gene silencing in vivo (Militello et al., 2025, Scientific Reports)
HDM-2-Targeting Peptide PNC-27 Kills Cervical Cancer Cells but not Normal Cervical Cells (Krzesaj et al., 2025, Ann Clin Lab Sci)
The Angiopoietin Signaling Pathway Is Involved in Inflammatory Processes in Hospitalized COVID-19 Patients (Mendoza et al., 2023, Microorganisms)
Endogenous spacing enables co-processing of microRNAs and efficient combinatorial RNAi (Amen et al., 2022, Cell Reports Methods)
Ephrin-A1 and the sheddase ADAM12 are upregulated in COVID-19 (Mendoza et al., 2021, Heliyon)
Administration of high titer convalescent anti-SARS-CoV-2 plasma: From donor selection to monitoring recipient outcomes (Mendoza et al., 2021, Hum Immunol)
Whether you are investigating gene function, screening potential drug candidates, or validating disease pathways and therapeutic targets, Mirimus is your trusted partner for in vitro services. Contact us today to learn how our custom models, assays, and screening platforms can help accelerate your research and development.
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