A revolution of  in vitro  culture for drug discovery.

IN VITRO TESTING SERVICES

At Mirimus, we provide comprehensive in vitro testing services designed to evaluate the efficacy, safety, and mechanisms of action of your therapeutic candidates. Leveraging both 2D and 3D cell-based models and our state-of-the-art equipment, our assays offer invaluable insights that closely mimic in vivo conditions, giving you a reliable understanding of how your compounds behave in complex biological environments.

Our laboratory is equipped with the latest technologies, including Incucyte live-cell analysis systems, flow cytometers, cell sorters, fluorescent microscopes, and robotic systems, which allow us to deliver cutting-edge solutions and high-throughput capabilities. Whether you're screening large libraries of compounds or investigating detailed mechanistic pathways, we provide the tools and expertise necessary to accelerate your research and development efforts.

2D Cell Models for High-Throughput Screening

Our 2D cell models, combined with our advanced robotic systems, provide an efficient and cost-effective way to screen large numbers of compounds for drug efficacy, toxicity, and mechanism of action. These models are ideal for both low- and high-throughput screening applications, allowing for rapid evaluation of therapeutic candidates with precision and reproducibility.

  • Low- and High-Throughput Screening: Our robotic systems streamline large-scale screening campaigns, enhancing throughput and data accuracy while minimizing hands-on time.
  • Diverse Cell Line Selection: We work with a wide range of cell lines, including primary human cells and immortalized cell lines, to ensure the most relevant model for your specific application.
  • Quantitative Readouts: With the Incucyte live-cell imaging system, we continuously monitor cell proliferation, morphology, and viability in real time, providing dynamic, quantitative insights into drug activity over time.

3D Cell Models for Complex Tissue-Like Environments

Recognizing the limitations of traditional 2D cell models, we offer advanced 3D cell models that more closely replicate the structural and functional complexity of in vivo tissues. These models are particularly valuable for studying more complex biological processes, such as tissue regeneration, cancer growth, and drug resistance.

  • Organoids: We develop organoid models that mimic the three-dimensional architecture of tissues, providing a more physiologically relevant environment for testing drug candidates.
  • Improved Predictability: By closely mimicking in vivo conditions, our 3D models offer better predictive power for how a drug will behave in the body.
  • Enhanced Mechanistic Insights: Our flow cytometers and cell sorters enable us to dissect complex cellular responses in 3D models, allowing for detailed exploration of drug effects on specific cell populations.

Development of Custom Functional Assays

Our team is highly skilled at developing and optimizing functional assays that are tailored to your specific research needs. We work closely with you to design assays that assess the biological function of your therapeutic candidates, from cell viability and proliferation to more specialized functions like receptor activation or metabolic activity.

  • Tailored Solutions: We design assays based on your unique requirements, ensuring that the data you receive is highly relevant to your research goals.
  • Diverse Assay Types: Using our flow cytometers and fluorescent microscopes, we offer a wide range of readouts, from cellular metabolic activity to complex signal transduction pathways.
  • Optimization and Scalability: Our assays are optimized for high sensitivity and reproducibility, and can be seamlessly integrated into high-throughput workflows using our advanced robotic systems for larger-scale projects.

Assay Validation for Mechanistic Studies

Our expertise extends beyond assay development to assay validation, where we rigorously test and validate assays to ensure reliability and accuracy. For mechanistic studies, we help you explore the underlying mechanisms of action of your drug candidates, such as target engagement, signal transduction pathways, and cellular responses.

  • Mechanistic Pathway Analysis: With tools such as flow cytometry and live-cell analysis using Incucyte, we can design and validate assays that probe specific pathways and molecular targets of your therapeutic candidates, providing deep insights into their function at the cellular level.
  • Biomarker Identification: Our fluorescent microscopes and flow cytometers are instrumental in identifying and tracking key biomarkers that can be used to measure therapeutic efficacy, toxicity, and mechanisms of action throughout the development process.
  • High Sensitivity and Specificity: Our validation processes ensure that all assays are rigorously tested for sensitivity, specificity, and reproducibility, providing you with reliable data to support your therapeutic development decisions.
Why Choose Mirimus for In Vitro Testing?

At Mirimus, we understand the importance of robust in vitro testing in the early stages of drug development. Our comprehensive in vitro platform, enhanced by cutting-edge equipment and technologies, accelerates the discovery and validation of therapeutic candidates, providing actionable data that guides decision-making throughout the development pipeline. We prioritize:

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Scientific Rigor

Our scientists employ the latest technologies to ensure that every assay is of the highest quality and relevance.

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Custom Solutions

We tailor our services to meet the unique needs of your project, offering flexibility in both assay design and implementation.

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Innovation and Expertise

With years of experience in cell-based assays and drug development, our team is equipped to tackle even the most complex challenges in drug discovery.

Whether you are conducting basic research, screening potential therapeutic candidates, or validating mechanistic pathways, Mirimus is your trusted partner for in vitro testing services. Contact us today to learn how we can help accelerate your drug development process.

CONTACT US

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760 Parkside Avenue, Suite 206
Brooklyn, NY 11226
info@mirimus.com
+1 (917) 830-6123