PRECLINICAL DRUG DISCOVERY SERVICES

Mirimus is your trusted partner in preclinical drug discovery, providing robust testing and development services across a range of therapeutic areas. Whether your focus is on small molecules, biologics, RNAi-based therapeutics, or CRISPR gene editing, our experienced team is equipped to support the development and testing of your candidates. With a balance of expertise in in-house development and preclinical testing of client-provided compounds, we aim to accelerate your path to clinical success.

SMALL MOLECULES

  • In Vitro Screening for Efficacy & Potency
  • Mechanistic & Target Engagement Studies
  • In Vivo Efficacy & Safety Assessment
  • PK/PD Profiling to Optimize Dosage & Administration
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BIOLOGICS

  • Functional Activity Assays for Efficacy
  • In Vitro & In Vivo Binding and Affinity Testing
  • Pharmacokinetic & Pharmacodynamic Profiling
  • Safety Assessment & Toxicity Studies
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RNAi SERVICES

  • Custom Design, Synthesis, and Validation of siRNA, shRNA, and artificial miRNA Triggers
  • Target Gene Assessment
  • Development of LNPs & Viral Delivery Systems
  • In Vitro & In Vivo Testing for Efficacy & Safety

CRISPR

  • Design & Validation of CRISPR Guide RNAs
  • Targeted Gene Knock-out/Knock-in for Therapeutic Development
  • CRISPR Screening for Functional Studies & Target Discovery
  • Functional Assays to Confirm Editing Efficacy

FORMULATIONS

  • Development of Stable & Bioavailable Formulations
  • LNP & Viral Vector Formulations for RNAi Delivery
  • Formulations for Various Routes of Administration (Oral, Injectable, Topical)
  • Bioavailability & PK Profiling for Improved Delivery

TOXICITY TESTING

  • In Vitro Cytotoxicity & Genotoxicity Testing
  • In Vivo Acute & Chronic Toxicity Studies
  • Dose-Response Analysis & Toxicokinetic Profiling
  • Safety Pharmacology & Biomarker Identification

PHARMACOKINETICS/
PHARMACODYNAMICS (PK/PD)

  • ADME Studies for Pharmacokinetic Profiling
  • In Vivo PK/PD Modeling for Dose Selection
  • Exposure-Response Relationships
  • Mechanistic Studies to Support Therapeutic Efficacy

Collaborate with Mirimus for Superior Preclinical Services

With a focus on both in-house development and client-provided compound testing, Mirimus offers a complete range of preclinical drug discovery services. Our expertise ensures that your small molecules, biologics, RNAi therapeutics, and CRISPR candidates are fully characterized, optimized, and ready for clinical advancement. Contact us today to learn how we can accelerate your drug discovery journey.

CONTACT US

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760 Parkside Avenue, Suite 206
Brooklyn, NY 11226
info@mirimus.com
+1 (917) 830-6123